The Kmif (Kveim-induced macrophage migration inhibition factor) test in sarcoidosis.
نویسندگان
چکیده
Circulating lymphocytes from 30 patients with sarcoidosis when stimulated in vitro with Kveim-induced macrophage migration factor, the Kmif test, produced a guinea-pig macrophage migration inhibition factor in 21 of 30 cases (70%). In those patients not on steroids the results showed a good correlation with the cutaneous Kveim test. One positive test was found in 16 normal subjects. Our results suggest that the Kmif test may prove a useful rapid alternative to the Kveim test.
منابع مشابه
The Kveim test in sarcoidosis.
The Kveim test with a validated test-suspension was found to give an overall 71-9% positive result. A very high figure was obtained among patients with hilar or paratracheal gland involvement. Despite our enumeration of the difficulties and drawbacks inherent in Kveim testing, we find that this is a valuable test, providing one is aware of the pitfalls. Despite the finding of positive tests in ...
متن کامل[Brompton Hospital, London].
Kveim tests were done in forty-eight patients with Crohn's disease. Of forty-five with definite or probable Crohn's disease, twenty-three had a positive Kveim test. This finding could be explained: (1) By cross-reactivity between sarcoidosis and Crohn's disease antigens; (2) By an aetiological agent common to the two diseases, or (3) By a property of the Kveim test material used in testing.
متن کاملBrompton Hospital, London
Kveim tests were done in forty-eight patients with Crohn's disease. Of forty-five with definite or probable Crohn's disease, twenty-three had a positive Kveim test. This finding could be explained: (1) By cross-reactivity between sarcoidosis and Crohn's disease antigens; (2) By an aetiological agent common to the two diseases, or (3) By a property of the Kveim test material used in testing.
متن کاملEarly cellular responses to intradermal injection of Kveim suspension in normal subjects and those with sarcoidosis.
In a detailed controlled study of the cellular response to Kveim suspension in vivo we used immunohistological and histochemical methods to examine cryostat sections of immature Kveim biopsy specimens in subjects with sarcoidosis and normal controls. Changes seen at 48 hours, at which time papular reactions have sometimes been reported, are described. Eight cases of sarcoidosis previously confi...
متن کاملPhytohaemagglutinin and transfer factor in the leucocyte migration inhibition test in patients with sarcoidosis.
A new system of phytohaemagglutinin stimulation in vitro using the leucocyte migration inhibition test has been applied to patients with active and inactive sarcoidosis and subjects with a persistently negative response to tuberculin. Patients with active sarcoidosis and the tuberculin-negative subjects have a depressed response to the mitogen. This response is improved by the addition of trans...
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ورودعنوان ژورنال:
- Journal of clinical pathology
دوره 25 11 شماره
صفحات -
تاریخ انتشار 1972